Ya-Chi Ho, MD, PhD

Assistant Professor of Microbial Pathogenesis and Medicine (Infectious Diseases)

Departments & Organizations

Microbial Pathogenesis: Ya-Chi Ho Lab

Faculty Research

Virology laboratories

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology: B and T Cell Effector and Memory Cell Differentiation; Infectious Disease and Host-Pathogen Interaction; Mounting an Immune Response | Microbiology: Immunology & Host Response; Molecular Genetics; Viruses


Dr. Ho takes a molecular virology approach to examine HIV persistence and develop HIV cure strategies. Using clinical samples from HIV-infected individuals, the Ho lab investigates host-HIV interactions with particular interests in single genome HIV proviral and vial sequencing, HIV epigenetic silencing, T cell biology and immune escape mechanisms. Dr. Ho, as an infectious disease attending physician in Taiwan, received her PhD and postdoctoral training at Johns Hopkins University School of Medicine. She was a tenure track instructor (2016) and then an assistant professor (2017) at Johns Hopkins School of Medicine before she joined Yale School of Medicine in 2017.

Education & Training

PhD Johns Hopkins University School of Medicine, Cellular and Molecular Medicine (2013)
MMS National Taiwan University, Clinical Medicine (2007)
MD National Cheng Kung University, Medicine (2002)
Postdoctoral fellow Johns Hopkins School of Medicine
Clinical fellow National Taiwan University Hospital
Resident National Taiwan University Hospital
Clinical clerkship Duke University Medical Center
Clinical clerkship Yale University

Honors & Recognition

  • Lois E. and Franklin H. Top, Jr. Yale ScholarYale University School of Medicine (2017)

  • Distinguished Alumni AwardNational Cheng Kung University (2016)

  • W. W. Smith Charitable Foundation AIDS Research AwardW. W. Smith Charitable Foundation (2016)

  • Phi Beta KappaPhi Beta Kappa Honorary Society (2014)

  • Michael Shanoff Johns Hopkins Young Investigator AwardJohns Hopkins University School of Medicine (2014)

  • Young Investigator AwardCROI (2013)

  • Howard Hughes International Student Research FellowshipHoward Hughes Medical Institute (2011)

  • Best Teaching Resident AwardNational Taiwan University Hospital (2007)

  • Scholarship for PhD Studies AbroadMinistry of Education, Taiwan (2007)

  • Best Resident AwardDepartment of Medicine, National Taiwan University Hospital (2003, 2004)

  • Phi Tau PhiPhi Tau Phi Honorary Society, Taiwan (2002)

Professional Service

  • Johns Hopkins University School of Medicine (2017 - Present) Assistant Professor of Medicine

  • AIDS Clinical Trial Group (2016 - 2017) Investigator, HIV Reservoirs and Viral Eradication Transformative Science Group

  • Johns Hopkins Center for AIDS Research (CFAR) (2016 - 2017) Co-Director, HIV Cure Scientific Working Group, Johns Hopkins CFAR

  • NIH Special Emphasis Panel Study Section (2016 - Present) Ad hoc reviewer

  • DC CFAR Faculty Developmental Grant Study Section (2016 - Present) Ad hoc reviewer

  • Johns Hopkins University School of Medicine (2015 - 2017) Instructor in Medicine

  • Johns Hopkins University School of Medicine (2014 - 2015) Research Associate

  • American Society for Microbiology (2011 - 2017) Member

  • National Taiwan University Hospital, Yun-Lin Branch (2007 - 2008) Attending Physician, Infectious Diseases

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Contact Info

Ya-Chi Ho, MD, PhD
Lab Location
Ya-Chi Ho LabBoyer Center for Molecular Medicine
295 Congress Avenue, Rm BCMM 349

New Haven, CT 06510
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Office Location
Boyer Center for Molecular Medicine
295 Congress Avenue, Rm BCMM 354E

New Haven, CT 06510
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Curriculum Vitae

Ya-Chi Ho Lab

The battle: HIV versus host restriction and immune clearance

Cells containing hypermutated HIV proviruses (red) may distract CD8+ T cells (green) from killing the cells containing infectious HIV (red). Cells containing proviruses with large internal deletions (blue) may expand over time due to lack of viral cytopathic effect and immune selection. Figure illustrated by Timothy Phelps.